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Understanding the pathophysiology of postpartum psychosis: challenges and new approaches

Davies, William 2017. Understanding the pathophysiology of postpartum psychosis: challenges and new approaches. World Journal of Psychiatry 7 (2) , pp. 77-88. 10.5498/wjp.v7.i2.77

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Abstract

Postpartum psychosis is a severe psychiatric condition which affects 1-2 of every 1000 mothers shortly after childbirth. Whilst there is convincing evidence that the condition is precipitated by a complex combination of biological and environmental factors, as yet the pathophysiological mechanisms remain extremely poorly defined. Here, I critically review approaches that have been, or are being, employed to identify and characterise such mechanisms; I also review a recent animal model approach, and describe a novel biological risk model that it suggests. Clarification of biological risk mechanisms underlying disorder risk should permit the identification of relevant predictive biomarkers which will ensure that ‘at risk’ subjects receive prompt clinical intervention if required.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Psychology
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Animal model; CCN3; Immune system; Mouse; Nephroblastomaoverexpressed; Risk factor; Steroid sulfatase
Publisher: Baishideng Publishing Group
ISSN: 2220-3206
Funders: Medical Research Council UK
Date of First Compliant Deposit: 25 April 2017
Date of Acceptance: 20 April 2017
Last Modified: 24 Apr 2019 13:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/100073

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